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Jun Wei Selected Research

WP1066

1/2022A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma.
1/2020Radiation with STAT3 Blockade Triggers Dendritic Cell-T cell Interactions in the Glioma Microenvironment and Therapeutic Efficacy.
12/2014Therapeutic targets in subependymoma.
7/2012The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models.
7/2009A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells.
9/2008A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells.

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Jun Wei Research Topics

Disease

94Neoplasms (Cancer)
08/2023 - 08/2004
28Glioma (Gliomas)
05/2024 - 02/2009
28Fibrosis (Cirrhosis)
10/2022 - 09/2008
26Schizophrenia (Dementia Praecox)
03/2024 - 05/2003
20Glioblastoma (Glioblastoma Multiforme)
01/2022 - 02/2009
17Systemic Scleroderma (Systemic Sclerosis)
10/2022 - 11/2010
15Lung Neoplasms (Lung Cancer)
01/2023 - 01/2011
14Inflammation (Inflammations)
05/2024 - 11/2010
13Infections
03/2024 - 02/2007
13Neoplasm Metastasis (Metastasis)
01/2023 - 09/2008
10Wounds and Injuries (Trauma)
01/2022 - 02/2008
9Breast Neoplasms (Breast Cancer)
02/2023 - 07/2011
9Carcinogenesis
06/2019 - 12/2008
9Melanoma (Melanoma, Malignant)
05/2019 - 09/2008
7Rheumatoid Arthritis
05/2024 - 01/2017
7Pain (Aches)
05/2024 - 07/2013
7Stomach Neoplasms (Stomach Cancer)
08/2022 - 03/2014
6Hypoxia (Hypoxemia)
04/2024 - 01/2011
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
01/2022 - 03/2014
6Prostatic Neoplasms (Prostate Cancer)
12/2020 - 05/2010
5B-Cell Lymphoma (Lymphoma, B Cell)
01/2024 - 07/2009
5Lung Diseases (Lung Disease)
09/2023 - 08/2013
5Pneumonia (Pneumonitis)
01/2022 - 05/2015
5Leukemia
03/2013 - 06/2005
4Myocardial Infarction
04/2024 - 01/2015
4Stroke (Strokes)
04/2024 - 03/2011
4Brain Neoplasms (Brain Tumor)
08/2023 - 07/2009
4Pulmonary Fibrosis (Fibrosing Alveolitis)
02/2023 - 11/2011
4Hemorrhoids
02/2023 - 11/2020
4Ischemic Stroke
01/2023 - 03/2011
4Spinal Cord Injuries (Spinal Cord Injury)
01/2022 - 04/2014
4Colorectal Neoplasms (Colorectal Cancer)
01/2020 - 01/2014
4Lymphoma (Lymphomas)
12/2017 - 04/2009
4Colonic Neoplasms (Colon Cancer)
09/2016 - 07/2013
3Hyperplasia
05/2024 - 01/2017
3Acute Kidney Injury (Acute Renal Failure)
04/2024 - 01/2024
3Intervertebral Disc Displacement (Herniated Disc)
04/2024 - 01/2021
3Non-alcoholic Fatty Liver Disease
02/2024 - 01/2021
3Prolapse
02/2023 - 01/2022
3Chronic Obstructive Pulmonary Disease (COPD)
01/2023 - 01/2017
3Asthma (Bronchial Asthma)
01/2023 - 11/2010
3Alzheimer Disease (Alzheimer's Disease)
08/2022 - 11/2010
3Adenocarcinoma of Lung
01/2022 - 01/2016
3Disease Progression
01/2022 - 04/2002
3COVID-19
06/2021 - 01/2020

Drug/Important Bio-Agent (IBA)

34Proteins (Proteins, Gene)FDA Link
03/2023 - 03/2002
23Biomarkers (Surrogate Marker)IBA
03/2024 - 05/2012
22AntibodiesIBA
03/2024 - 04/2002
21MicroRNAs (MicroRNA)IBA
12/2022 - 12/2011
21AntigensIBA
05/2022 - 04/2002
19Immunoglobulin G (IgG)IBA
03/2024 - 01/2011
18CytokinesIBA
05/2024 - 05/2003
15Peptides (Polypeptides)IBA
03/2024 - 03/2014
14Therapeutic UsesIBA
09/2023 - 07/2013
14EnzymesIBA
01/2023 - 06/2013
10AutoantibodiesIBA
03/2024 - 10/2012
9Bleomycin (Blenoxane)FDA LinkGeneric
02/2020 - 06/2011
9Transforming Growth Factors (Transforming Growth Factor)IBA
01/2020 - 03/2011
9STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
05/2016 - 12/2008
7DNA (Deoxyribonucleic Acid)IBA
01/2021 - 04/2002
7ImmunosorbentsIBA
12/2020 - 06/2013
6LipidsIBA
02/2024 - 07/2016
6WP1066IBA
01/2022 - 09/2008
6CollagenIBA
01/2021 - 09/2008
6Peroxisome Proliferator-Activated Receptors (PPAR)IBA
02/2014 - 11/2010
5RNA (Ribonucleic Acid)IBA
08/2023 - 11/2016
5Interleukin-6 (Interleukin 6)IBA
07/2023 - 05/2014
5Transcription Factors (Transcription Factor)IBA
10/2021 - 05/2011
5RetinoidsIBA
06/2020 - 01/2015
5CateninsIBA
01/2020 - 11/2011
5InterleukinsIBA
01/2019 - 05/2011
5LigandsIBA
03/2018 - 11/2010
5Toll-Like Receptors (Toll-Like Receptor)IBA
10/2017 - 03/2011
51,1',6,6',7,7'- hexahydroxy- 3,3'- dimethyl- N5- (2- phenylpropyl)- N5'- (2- phenylpropyl)- 2,2'- binaphthyl- 5,5'- dicarboxamideIBA
06/2015 - 05/2010
4HydrogelsIBA
05/2024 - 08/2012
4Anti-Bacterial Agents (Antibiotics)IBA
03/2024 - 09/2017
4AntioxidantsIBA
02/2023 - 01/2018
4IntegrinsIBA
01/2022 - 10/2011
4AdiponectinIBA
01/2017 - 05/2012
4Transforming Growth Factor beta (TGF-beta)IBA
08/2014 - 09/2008
4apogossypolIBA
05/2011 - 04/2009
3ChemokinesIBA
05/2024 - 12/2014
3Glucose (Dextrose)FDA LinkGeneric
04/2024 - 01/2012
3Protein Kinases (Protein Kinase)IBA
12/2023 - 10/2012
3Betaine (C.B.B.)FDA Link
12/2023 - 11/2013
3Messenger RNA (mRNA)IBA
08/2023 - 06/2014
3Amyloid (Amyloid Fibrils)IBA
08/2022 - 01/2017
3AcidsIBA
05/2022 - 02/2014
3OsteopontinIBA
01/2022 - 01/2019
3Small Interfering RNA (siRNA)IBA
01/2022 - 06/2017
3Interleukin-10 (Interleukin 10)IBA
01/2022 - 02/2007

Therapy/Procedure

63Therapeutics
05/2024 - 09/2008
11Drug Therapy (Chemotherapy)
05/2024 - 02/2009
9Immunotherapy
01/2021 - 02/2009
7Radiotherapy
01/2023 - 02/2009
4Transplantation
09/2023 - 10/2016
3Local Anesthesia
04/2024 - 09/2009
3Diskectomy (Discectomy)
04/2024 - 01/2021
3Ligation
02/2023 - 01/2015
3Hemorrhoidectomy
02/2023 - 11/2020